Research Scientist-Immune Cell Redirection and Strategy - New York City (Manhattan), New York, United States,
Lilly's Immuno-Oncology Research and Development Center of Excellence in New York City is seeking a highly motivated Scientist to contribute to the development of cancer therapeutics in the Cancer Immunobiology department. The ideal scientist is expected to have a broad knowledge of cancer immunology with prior academic and/or industry experience and publications in the field.
You will be responsible for leading a group of scientists to support drug discovery and development in the area of T cell redirection within the immune oncology discovery area at the Lilly NY laboratories. Some responsibilities will be in contributing to novel redirection strategies as well as the overall Immuno-Oncology portfolio. Both target identification and target validation work will be required, including independently designing and carrying out experiments, directly overseeing Research Associates in their day-to-day work, and utilizing the broader Lilly resources in a matrixed fashion to achieve goals. Ultimately it is expected that drug candidates will be carried into clinical development. This role involves both leading aspects of laboratory experiments as well as performing laboratory experiments which are designed to understand the mechanism of action of pipeline cancer therapeutics. Examples include but are not limited to
- developing and performing in vitro and in vivo models and assays;
- mammalian cell culture (primary immune cell isolation/culture), transfections, stable clone generation; flow cytometry and immunophenotyping;
- cell based and immunological assays including proliferation, effector function, reporter assays, T cell activation, antigen specific T cell isolation and characterization, T cell tumor killing.
You may also function as scientific team lead including leading and participating in project team meetings and providing written and verbal communication of work, presentation of data and data summaries internally and externally as needed.
Do you have a broad understanding of basic immunology as well as cancer immunobiology? This includes expertise in aspects of T cell priming, expansion and suppression. Experience in the area of T cell redirection is critical. It is desired to also have expertise in mechanisms of tumor mediated immune suppression. Excellent communication skills and the ability to work well independently and in a team setting are required in this role. Collaboration and teamwork are cornerstones of our research requiring you to work both independently as part of a multi-disciplinary teams and across functional areas.
- PhD in Biological Sciences (e.g. Immunology, Tumor Immunology, Cell Biology or closely related discipline).
- Prior post-doctoral and/or industry research experience in the Immuno-Oncology setting highly preferred.
Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.